How does retinal help the eye turn light into a nerve signal?
Retinal, an aldehyde derived from vitamin A, is essential to the process of vision. It functions as a light-sensitive component of rhodopsin, a protein complex found in the retina of the eye.123
When light enters the eye and is absorbed by rhodopsin, it triggers a process called photoisomerization. Specifically, the retinal molecule—which is initially in a folded shape known as 11-cis-retinal—is twisted into a straighter configuration called all-trans-retinal.41
This change in molecular geometry causes the attached protein, opsin, to alter its own shape. This structural shift activates a protein called transducin, which initiates an internal biochemical pathway. These chemical events act as a trigger, altering the release of neurotransmitters and generating electrical impulses that are sent along the optic nerve to the brain, where they are interpreted as visual signals.123