How does pseudogout differ from gout?

While both gout and pseudogout are forms of crystalloid arthritis that cause joint inflammation and pain, they differ significantly in their underlying pathology and clinical presentation.1

Key Differences

• Crystal Composition: Gout is caused by the deposition of needle-shaped monosodium urate crystals, which result from elevated levels of uric acid in the blood (hyperuricemia). Pseudogout is caused by the deposition of rhomboid-shaped calcium pyrophosphate crystals (CPPD).12
• Causes: Gout is a metabolic disorder often linked to purine metabolism, diet, and kidney function. Pseudogout is frequently associated with elevated pyrophosphate levels in synovial fluid, often triggered by trauma, surgery, or underlying conditions like hyperparathyroidism or hemochromatosis.12
• Demographics: Gout is significantly more common in men, particularly those in their 40s. Pseudogout affects both men and women, with prevalence increasing significantly in individuals aged 85 and older.12
• Joint Involvement: While gout often targets the big toe, it can affect various joints. Pseudogout typically involves one or two joints, such as the knees, wrists, or shoulders.12