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How does physostigmine increase the effects of acetylcholine?

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Physostigmine increases the effects of acetylcholine by acting as an anticholinesterase drug.1

Normally, the enzyme acetylcholinesterase rapidly inactivates acetylcholine at cholinergic synapses by breaking it down into choline and acetate. Physostigmine inhibits this enzyme, preventing the destruction of the neurotransmitter. By blocking the breakdown process, physostigmine allows higher levels of acetylcholine to accumulate at its sites of action, thereby prolonging and enhancing its physiological effects, such as muscle contraction and parasympathetic nervous system stimulation.23145