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How does epinephrine prevent blood glucose from becoming too low during an emergency?
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Hormone
Many important physiological functions of vertebrates are controlled by steroid hormones.
During an emergency, epinephrine prevents blood glucose from dropping too low through several coordinated mechanisms that prioritize energy availability for the body.12
- Inhibition of Insulin: Epinephrine binds to -adrenoceptors on the pancreas, which inhibits the release of insulin. Because insulin normally promotes the uptake of glucose into tissues, suppressing it ensures more glucose remains in the bloodstream for the brain.1
- Stimulation of Glucagon: By binding to specific -adrenoceptors, epinephrine triggers the release of glucagon. This hormone acts on the liver to convert stored glycogen into glucose.13
- Metabolic Mobilization: Epinephrine directly stimulates the breakdown of glycogen in the liver and skeletal muscle into glucose. Additionally, it promotes the conversion of fat in adipose cells into fatty acids and glycerol, and increases the production of glucose and ketone bodies in the liver, providing alternative energy sources for the body during stress.12