How does bicarbonate from the pancreas protect the small intestine from stomach acid?

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When acidic chyme—a mixture of food and gastric secretions—enters the duodenum from the stomach, it triggers the release of the hormone secretin into the bloodstream.12

Secretin acts as a chemical messenger that stimulates the duct cells of the pancreas to secrete water and bicarbonate. These pancreatic secretions travel through ducts into the descending duodenum, where the bicarbonate promptly neutralizes the hydrochloric acid present in the gastric mixture. By diluting and neutralizing this acid, the pancreas protects the delicate mucosal lining of the small intestine from potential damage.132