How does Hensen's node function during gastrulation in birds and higher mammals?

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During gastrulation in birds and higher mammals, Hensen’s node functions as a primary organizer, playing a role analogous to the dorsal lip of the blastopore in amphibian embryos. Located at the anterior end of the primitive streak, this thickened mass of cells is essential for orchestrating the organization of the developing embryo.12

Key functions of Hensen’s node include:

  • Formation of the Notochord: The node serves as the source from which the notochord—the embryo's primary longitudinal supporting structure—is proliferated.3
  • Embryonic Induction: As a primary organizer, the node and the anterior end of the primitive streak exert an inducing influence on surrounding tissues. This process, known as embryonic induction, directs the differentiation of the overlying ectoderm into the neural plate and influences the development of other organ rudiments.1
  • Structural Organization: By facilitating the movement and interaction of cell groups, Hensen’s node helps establish the spatial relationships necessary for the development of the vertebrate body plan.1