How do the epimysium, perimysium, and endomysium support skeletal muscle?

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Skeletal muscle is organized by layers of connective tissue that provide structural support and facilitate the transmission of force generated by muscle fibers to tendons and bones. These layers are organized as follows:1

  • Endomysium: This is the connective tissue layer that surrounds individual muscle fibers.
  • Perimysium: This layer surrounds bundles of muscle fibers, which are known as fascicles.1
  • Epimysium: This is the external connective-tissue sheath that surrounds the entire muscle.2

Together, these connective tissues serve a critical mechanical role by helping to transmit the force produced by the contraction of myofibrils within the muscle fibers to the tendons, ultimately enabling body movement.1