How do bupropion and atomoxetine affect norepinephrine in the brain?

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Both bupropion and atomoxetine are nonstimulant medications used in the treatment of attention-deficit/hyperactivity disorder (ADHD). These drugs function by inhibiting the reuptake of the neurotransmitter norepinephrine from nerve terminals. By blocking this reuptake process, they increase the amount of norepinephrine available in the brain, which helps improve concentration and focus in affected individuals.1