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How do aminoglycosides stop bacteria from making proteins?

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Aminoglycosides function as antimicrobial agents by targeting the machinery responsible for building bacterial proteins.

Once these drugs are transported into susceptible bacterial cells, they bind to ribosomes. Ribosomes are the essential organelles that facilitate protein synthesis. By binding to these structures, aminoglycosides effectively inhibit the process of protein synthesis, which prevents the bacteria from functioning and ultimately leads to the death of the bacterial cell.1