How could cross-links in enzyme molecules interfere with cell function?

According to the cross-linking theory of aging, the formation of cross-links within or between enzyme molecules can significantly interfere with cellular function.1

Enzymes rely on a precise molecular structure and shape to catalyze biochemical reactions effectively. When cross-links form, they alter this specific configuration, which can prevent the enzyme from performing its biological role within the cell. Because an enzyme's ability to catalyze a reaction depends on its ability to bind substrates at a specific active site, any structural distortion caused by cross-linking may render the enzyme unable to form the necessary enzyme-substrate complex. This loss of catalytic activity is a common consequence of structural modification, similar to the loss of function observed during protein denaturation.123