How can lung cancer cause chest pain?

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In the context of lung cancer, chest pain can occur when the malignant disease spreads to involve the pleura, the membrane surrounding the lungs. Additionally, chest pain may arise from a tumour that originates directly from the pleura, such as in cases of mesothelioma.1

While severe, intractable pain from these conditions is considered rare, it may occasionally require surgery to sever the nerves supplying the affected area.1