How can glucocorticoid medications slow the progression of Duchenne muscular dystrophy?

In the context of Duchenne muscular dystrophy (DMD), glucocorticoid steroids are used to slow the progression of the disease primarily by combating the inflammation associated with muscle breakdown.1

By reducing this inflammation, the treatment helps individuals maintain the ability to walk for a longer period of time and can improve heart function. While these medications are a standard part of the treatment model, they are associated with several potential side effects, including osteoporosis, mood swings, appetite changes, delayed puberty, water retention, and suppression of the immune system.1