How can a complete blood count help identify an infection?

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A complete blood count (CBC) helps identify an infection by measuring the total number and types of white blood cells present in the blood. In a healthy individual, the immune system typically responds to an infection by increasing the production of these cells.12

A differential white blood cell count provides further diagnostic insight by identifying which specific types of white blood cells are abnormal:

  • Viral infections: These typically affect the lymphocyte count.2
  • Bacterial infections: These often lead to an increase in the percentage of band neutrophils.2
  • Parasitic infections: These may cause an increase in eosinophils.2

While an increase in white blood cells (leukocytosis) is a common sign of infection, some infections or conditions can cause a decrease in white blood cell numbers, a state known as leukopenia. By analyzing these fluctuations, clinicians can gain essential information regarding the presence and potential nature of an infection.312