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How are lysosomal enzymes marked in the cis-Golgi network?
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Golgi apparatus
A membrane-bound organelle of eukaryotic cells, the Golgi apparatus is made up of a series of flattened, stacked pouches called cisternae that function as a series of compartments that progressively refine and direct cellular products to their proper destinations. .
In the cis-Golgi network, lysosomal enzymes are marked for their specific destination through the addition of phosphate groups to their carbohydrate residues.1
This modification is a critical sorting mechanism that distinguishes lysosomal enzymes from secretory proteins, which are initially found together in the endoplasmic reticulum. Once these enzymes are phosphorylated, they are able to bind to specific receptors located on the membrane of the Golgi apparatus. This binding interaction ensures that the enzymes are packaged into specialized vesicles directed toward the lysosome rather than being routed into the secretory pathway.1