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How are chickenpox and shingles caused by the same virus?

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Chickenpox and shingles are both caused by the varicella-zoster virus (VZV). The two conditions represent different stages of the virus's lifecycle within the human body.12

  • Chickenpox: This is the clinical manifestation of a primary infection, typically occurring during childhood. Following this initial exposure, the virus does not leave the body.12
  • Latency: After recovery from chickenpox, the virus remains dormant (latent) within sensory neurons or nerve ganglia.12
  • Shingles (Herpes Zoster): Years or even decades later, the latent virus may be reactivated, often due to factors like reduced immunity. Once reactivated, the virus travels along nerve pathways to the skin, where it causes the painful, blistered rash characteristic of herpes zoster.12

While a person with shingles can transmit VZV to someone who has never had chickenpox or been vaccinated, that individual will develop chickenpox, not shingles. Shingles itself is strictly the result of the reactivation of the virus already present in the host's own nervous system.12