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At what age does severe thalassemia often begin to cause anemia?
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blood disease
Peripheral blood smear revealing histopathologic features indicative of a blast crisis in a case of chronic myelogenous leukemia (CML). Blast crisis occurs when one-fifth to one-third of the cells in the blood or bone marrow are immature blood cells, or blast cells. This phase of CML is characterized by fever, weakness, and an enlarged spleen.
In cases of thalassemia major—the most severe form of the disorder—clinical symptoms such as anemia, an enlarged spleen, and often an enlarged liver typically begin to appear a few months after birth.1