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Which MLB team lost the most games in a single season?

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The Editors of Encyclopaedia Britannica
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The Editors of Encyclopaedia Britannica

In the 2024 season the Chicago White Sox finished with 121 losses, which set a new Major League Baseball record for most losses in a single season. The previous record of 120 losses had been set by the New York Mets in 1962. Among the lowlights for the White Sox during the 2024 season was a 21-game losing streak, which tied the American League record.