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What role is Patrick Dempsey best known for?

Patrick Dempsey is best known for playing neurosurgeon Derek Shepherd, nicknamed “McDreamy,” on the medical drama Grey’s Anatomy (2005– ). He was a series regular from 2005 through 2015 and returned in season 17 in a series of visions experienced by Meredith Grey. The role brought him a large fan following and significantly raised his profile.