Patrick Dempsey has appeared in films and television series including Can’t Buy Me Love (1987), Scream 3 (2000), Sweet Home Alabama (2002), Enchanted (2007), Made of Honor (2008), Bridget Jones’s Baby (2016), Will & Grace, Once and Again, The Truth About the Harry Quebert Affair (2018), Dexter: Original Sin (2024–25), and Memory of a Killer (2026). He is best known for playing neurosurgeon Derek Shepherd, on several seasons of Grey’s Anatomy (2005– ).
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