Proteins made at the rough endoplasmic reticulum may enter its inner space, known as the lumen, or become part of its membrane. In the lumen, proteins can be modified, including by removal of signal sequences or by glycosylation, which adds an oligosaccharide to form a glycoprotein. Proteins also take on their three-dimensional shapes. Some are then packaged into vesicles and sent to the Golgi apparatus, while others remain in the ER.
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