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What are the side effects of heavy methamphetamine use?

Heavy methamphetamine use can cause a wide range of serious physical and psychological side effects, including extreme weight loss, severe dental problems, skin sores, and increased heart rate and blood pressure, which elevate the risk of heart attack or stroke. It can also damage the brain, leading to memory loss, impaired judgment, and difficulty concentrating. Psychologically, methamphetamine use is often associated with anxiety, paranoia, aggression, hallucinations, and psychosis, and long-term use can result in addiction, mood disturbances, and lasting changes in brain function that significantly affect behavior and overall quality of life.