Clozapine is known as a second-generation antipsychotic, and it therefore differs from first-generation agents. The primary difference is that clozapine blocks both serotonin receptors and dopamine receptors. Unlike first-generation antipsychotics that solely and strongly block dopamine receptors, clozapine weakly inhibits these receptors. It therefore has a low risk of extrapyramidal side effects and has minimal impact on blood prolactin levels, which are significantly affected by dopamine inhibition.
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