Only twice in the history of the NCAA men’s basketball tournament has a number one seed lost to a 16 seed. In 2018 Virginia (the overall number one seed) became the first to lose when it was upset by the 16th-seeded team from the University of Maryland, Baltimore County, 74–54. The second such upset occurred in 2023, when Purdue was defeated by Fairleigh Dickinson, 63–58.
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