Why did the first settlement of Buenos Aires fail?

The first settlement of Buenos Aires, founded by Pedro de Mendoza in 1536, failed primarily due to a critical lack of food and persistent attacks by Indigenous peoples.123

Mendoza, who was suffering from illness and struggling to maintain control over his expedition, eventually abandoned the site and sailed for Spain in 1537, dying during the voyage. The remaining settlers managed to hold the location for five years before ultimately abandoning it in 1541 to relocate to Asunción, which became the first permanent settlement in the region.123