Why did the Nazis destroy the Great Synagogue of Warsaw?

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The Nazis destroyed the Great Synagogue of Warsaw as a final, symbolic act of destruction following the Warsaw Ghetto Uprising.

After the Warsaw Ghetto resistance was suppressed in May 1943, SS Major General Jürgen Stroop supervised the dynamiting of the synagogue to mark the conclusion of the operation. This act was intended to symbolize the total annihilation of the city's Jewish community, effectively ending six centuries of Jewish history in Warsaw.123