Which river flowed through ancient Babylon during its greatest period?

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The river that flowed through ancient Babylon during its greatest period was the Euphrates.

During the reign of Nebuchadnezzar II, when Babylon became the largest city in the world, the Euphrates served as a central feature of the city's topography. The river divided the city into eastern and western halves, which were connected by a bridge, and its banks were lined with quays for trading vessels. While the river has shifted its course since that time, it was integral to the city's role as a major commercial and administrative center within the Tigris-Euphrates river system.123