Why are pigs thought to play a role in the emergence of new influenza A viruses?
Pigs are considered significant in the emergence of new influenza A viruses because they can serve as "mixing vessels" for different viral strains.12
When a pig is simultaneously infected with multiple influenza A virusesāsuch as human, swine, and avian strainsāthe viruses can undergo a process called genetic reassortment. During this process, the viruses exchange genetic material, which can lead to the creation of a new, distinct influenza subtype.3124
This mechanism is particularly dangerous for humans because the resulting virus often possesses novel antigens to which the human population has little or no pre-existing immunity. This lack of immunological protection is a primary driver of pandemics, as seen in the 2009 H1N1 outbreak, which is believed to have evolved through such reassortment in pigs.4231