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Great Famine, famine that occurred in Ireland in 1845–49 when the potato crop failed in successive years. The crop failures were caused by late blight, a disease that destroys both the leaves and the edible roots, or tubers, of the potato plant. The causative agent of late blight is the water mold Phytophthora infestans. The Irish famine was the worst to occur in Europe in the 19th century. In the early 19th century, Ireland’s tenant...