Why did Giuseppe Verdi's demanding work schedule between 1843 and 1849 harm his health?

Between 1843 and 1849, Giuseppe Verdi’s health suffered because he drove himself to produce nearly two operas a year. His intense workload was motivated by a desire to earn enough money to retire early as a gentleman farmer.12

The process of producing an opera during this period was exceptionally demanding, requiring Verdi to:
* Negotiate with an impresario1
* Secure and heavily edit the libretto1
* Find or approve singers1
* Compose the music1
* Supervise rehearsals and conduct the first three performances1
* Manage dealings with publishers1

These responsibilities were compounded by the necessity of constant travel across Italy, which he had to navigate in the era before the development of railroads.1