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Which film first paired William Powell and Myrna Loy as an on-screen duo?
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W.S. Van Dyke
W.S. Van Dyke (standing, right) directing Myrna Loy and William Powell during the filming of The Thin Man (1934); cinematographer James Wong Howe is on the left.
The film that first paired William Powell and Myrna Loy as an on-screen duo was Manhattan Melodrama (1934).12
Following this initial collaboration, the two actors became one of Hollywood's most popular pairings, most notably starring as the husband-and-wife detective team Nick and Nora Charles in the film The Thin Man, which was also released in 1934.123