Britannica Sources used in this answer

Norman Taurog - Martin and Lewis films of Norman Taurog

Which actors played the adoptive parents in Room for One More?

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Director Norman Taurog, wearing a hat and glasses, sits beside actor Mickey Rooney, who is smiling, on the set of the film Boys Town, with camera equipment visible behind them. — Norman Taurog Norman Taurog (right) with Mickey Rooney on the set of Boys Town (1938).

In the 1952 film Room for One More, directed by Norman Taurog, the adoptive parents were played by Cary Grant and Betsy Drake, who were married in real life.1