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When did John Milton become completely blind?

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Engraved portrait of John Milton by Jacob Houbraken, showing Milton with shoulder-length hair, a lace collar, and period clothing, facing forward in an oval frame. — John Milton John Milton, engraving by Jacob Houbraken, 1741.

John Milton became completely blind shortly after the publication of his 1651 work, Defense of the English People Against Salmasius. While the exact cause is not definitively confirmed, it is widely believed that his blindness was the result of glaucoma.1