What was Gaetano Donizetti’s last important opera?

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Gaetano Donizetti’s last important opera was Dom SĆ©bastien, which premiered at the Paris OpĆ©ra in 1843.1

At the time of its composition, Donizetti was suffering from the effects of a fatal disease, which caused him significant physical and mental strain. Although the work received unfavorable reviews from critics, it was considered a success with the public.1