What threat drives the manhunt in Panic in the Streets?

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Elia Kazan stands on a docked ship set with arms outstretched, directing a scene for Panic in the Streets in New Orleans, with crew members and rigging visible behind him. — Elia Kazan Elia Kazan on the set of *Panic in the Streets*, 1950.

In the 1950 film Panic in the Streets, directed by Elia Kazan, the manhunt is driven by the urgent need to locate criminals who are unknowingly carrying an infectious plague.