What is known about the cause of Sandro Botticelli’s death?

The specific cause of Sandro Botticelli’s death in 1510 is not definitively known or widely documented.1

While the biographer Giorgio Vasari characterized the artist as being impoverished and disabled during his final years, this account is contradicted by other evidence indicating that Botticelli and his family remained relatively prosperous and that he continued to pay dues to the Company of Saint Luke as late as 1505. It is generally suggested that his lack of new commissions and the declining quality of his final Dante drawings imply that he was likely overtaken by general ill health.21