What events caused problems during rehearsals for Claudio Monteverdi’s L’Arianna?

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During the rehearsals for Claudio Monteverdi’s opera L’Arianna in 1608, the production faced a tragic setback when the prima donna died of smallpox. The young woman had been living in Monteverdi’s home, possibly as a pupil of his late wife, who had also passed away only months earlier. Despite this loss, the role was recast, and the opera was successfully produced in May 1608.1